Mechanisms of spermidine-induced autophagy and geroprotection

In this review published in Nature Aging (2022), Hofer et al review novel insights into the geroprotective mode of action of spermidine at the molecular level and discuss strategies for elucidating its clinical potential.

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Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model

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Spermidine supplementation influences mitochondrial number and morphology in the heart of aged mice